The most important chemical components of Curcuma longa are a group of compounds called curcuminoids, which include curcumin diferuloylmethane, demethoxycurcumin, and bisdemethoxycurcumin. The best-studied compound is curcumin, which constitutes 3.14% (on average) of powdered turmeric. In addition, other important volatile oils include turmerone, atlantone, and zingiberene.
Curcuminoids act as a superoxide radical scavenger as well as singlet oxygen quencher and gives the antioxidant its effectiveness. Tetrahydrocurcumin, one of the main metabolites of curcumin, is the most potent antioxidant among the naturally occurring curcuminoids.
The curcuminoids are capable of inhibiting damage to super coiled plasmid DNA by hydroxyl radicals. It was concluded that the derivatives of curcumin are good in trapping the 2,2-diphenyl-1-picrylhydrazyl(DPPH) radical as efficiently as curcumin which is a well known antioxidant.
DPPH has two major applications, both in laboratory research: one is a monitor of chemical reactions involving radicals, most notably it is a common antioxidant assay, and another is a standard of the position and intensity of electron paramagnetic resonance signals.
Anti-inflammatory effects of curcumin and its derivatives are because of the hydroxyl and phenol groups in the molecules. These groups are essential for inhibition of prostaglandin synthetase and leukotrienes synthesis. A system with conjugated double bonds or dienes is also believed to be responsible for the anti-inflammatory effect as well as antiparasitic activity.
The properties of curcumin include the induction of cellular defense detoxifying and antioxidant enzymes, which can protect against cellular damage caused by environmental carcinogens or endogenously generated reactive oxygen species. These compounds can also affect cell-death signaling pathways, which prevent the proliferation of tumor cells.
One activator of antioxidant and anticancer genes appears to be Nuclear factor-erythroid-2-related factor 2 (Nrf2). Nrf2 is the master regulator of the body’s aging process. When Activated, Nrf2 enters the nucleus of a cell and helps the body function at an optimal level.
Curcumin activates Nrf2 signaling in skeletal muscles; in cell culturing system and in haem oxygenase-1 via regulation of Nrf2 and the ontioxidant-responsive elelment.
Curcumin has also been shown to improved insulin signaling and glucose disposal, associated with the attenuation of muscle mitochondrial oxidative stress.
Curcumin, can enhance the cancer-fighting power of treatment with tumor necrosis factor-related apoptosis-inducing ligand., a naturally occurring molecule that helps kill cancer cells. In an experiment with human Prostate cancer cells in a laboratory dish, the combination treatment killed off two to three times more cells than either treatment alone.
Curcumin is involved in Erectile signaling via elevation of cyclic guanosine monophosphate (cGMP)
Water-soluble curcumin could enhance Erectile Function with more effectiveness and with more prolonged duration of action.
Health also reflects the ability of an organism to adapt to stress.
Stresses—metabolic, proteotoxic, mitotic, oxidative and DNA-damage stresses—not only contribute to the etiology of chronic degenerative diseases but are also hallmarks of the cancer phenotype.
Organic Curcuma longa ( Curcumin) Extract:
Stress Reduction – Neurodynamic Therapies: